Ibutamoren: powerful secretagogue of growth hormone

Ibutamoren is a peptidomimetic, which acts as a stimulator of growth hormone secretion and perfectly imitates the action of ghrelin. It is known that Ibutamoren increases the release of several hormones (IGF-1, IGF-1, growth hormone), and supports their plasma levels, but what is important - it is absolutely has no influence on the level of endogenous cortisol. Besides, Ibutamoren facilitates rapid recruitment of lean muscle mass, improve bone mineral density, as well as speeding up the metabolism of fats in the body. And although today MK-677 is still in the development stage, it is planned that it will be actively used in the near future as a cure for growth hormone deficiency among children and the elderly, as well as the treatment of bone fragility and obesity.

MK-677 is included in a wide range of different studies, each of them demonstrates its high positive efficiency.

Anabolic Brew Ibutamoren is a safe and effective alternative to HGH and is made of high-quality raw materials tested by liquid chromatography.

Research results

Here are the data of a randomized, double-blind, parallel, placebo-controlled research published on the Pubed website. It was attended by 24 men, obese, aged 18 to 50 years. Within 8 weeks of 12 men were given 25 mg of Ibutamoren per day, while the other group received a placebo

…It was concluded that the 2-month use of MK-677 by healthy obese men increases serum levels of growth hormone, IGF-I and IGF-binding protein-3. Effect on cortisol secretion was temporary. The observed changes in body composition and energy expenditure were anabolic in nature, with a steady increase in body mass without fat, and a temporary increase in the basic metabolism…

Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure"

In addition, there are the results of another double-blind, randomized, placebo-controlled research, which lasted for 2 years. It took 65 healthy adults between the ages 60 to 81 years. The members of first group were given 25 mg of drug per day, while members of the second group received placebo. The study found that Ibutamoren can be used long term without compromising its effectiveness.

…For 12 months MK-677 caused an increase in the secretion of growth hormone, a significant increase in body mass without fat, and in general proved to be well-tolerated substance.

"Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial"

Effects

  • increase of lean muscle mass;
  • strengthening of bone tissue;
  • rapid healing of injured ligaments and tendons;
  • an increase of IGF-1 level;
  • improves athletic performance and endurance;
  • reduction of adipose tissue;
  • improvement of the overall condition of the skin;
  • improvement of health.

Side effects

Perhaps a temporary numbness of the hands, sleep anxiety, and increased appetite.

How to use

25 mg daily for 10-12 weeks.

Sourses:

  1. http://www.ncbi.nlm.nih.gov/pubmed/11452249
  2. http://www.ncbi.nlm.nih.gov/pubmed/9467542
  3. http://www.ncbi.nlm.nih.gov/pubmed/?term=Two-year+treatment+MK-677